Two separate laboratory breakthroughs have produced RNA molecules that can build copies of themselves or assemble functional structures without any help from proteins or DNA. These results offer the ...

A 45-nucleotide strand of RNA can now synthesize both its mirror-image complement and a copy of itself, bringing scientists closer than ever to demonstrating how life could have emerged from chemistry ...

These random molecules were fed a collection of three-base-long RNAs, each linked to a chemical tag. The idea was that if a molecule is capable of ligating one of these short RNA fragments to itself, ...

A strand of RNA just 45 nucleotides long has been discovered to perform two key reactions required for self-replication. The ...

The discovery of catalytic RNA transformed our understanding of life's beginnings. Clare Sansom explores how the RNA world ...

Drug developers & researchers can now leverage the CleanScribe enzyme to reduce dsRNA formation by up to 85% in mRNA synthesis without compromising mRNA yield, capping efficiency, or integrity ...

Figure 1: An illustration showing RNA polymerase II (silver structure) transcribing DNA (yellow and orange helix) into messenger RNA. RIKEN researchers have conducted a structural study of the ...

SAN DIEGO--(BUSINESS WIRE)--TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces ...

Researchers developed C28, an engineered polymerase that efficiently synthesizes RNA at near-natural speeds with high accuracy. Created through directed evolution, the enzyme also performs reverse ...

AI can help protein engineers optimize the transcription enzymes used to make mRNA-based vaccines and therapeutics, say the authors of a new study.