Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, ...

cThe Section of Hematology/Oncology, Department of Internal Medicine, University Hospital of Kiel, Germany dThe Department of Pathology, University of Kiel, Germany The phylogenetic antiquity of DNA ...

This review examines the cellular functions of the DNA topoisomerases from a mechanistic point of view. The following points are summarized. Classification of DNA topoisomerases into four subfamilies ...

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Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression ...

Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are ...