The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication. Functional studies of the HCV IRES have ...

Bacterial protein synthesis requires the assembly of the 30S and 50S ribosomal subunits on mRNA to form the translationally competent 70S complex. Nontranslating 70S ribosomes homodimerize into a ...

1 School of Life Sciences, University of Westminster, London, United Kingdom 2 Pathogen Gene Regulation Unit, Instituto de Biomedicina de Valencia (IBV), CSIC, Valencia, Spain A recent addition to the ...

Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States ...

Selenoproteins are proteins that contain the rare amino acid selenocysteine (Sec), typically found in their catalytic centers. Because Sec exhibits superior catalytic properties and can resist ...

1 Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy 2 Biochemistry III – Regensburg Center for Biochemistry, Institute for Biochemistry, Genetics and Microbiology, University ...

Regulation of translating ribosomes is a major component of gene expression control network. In Escherichia coli, ribosome stalling by the C-terminal arrest sequence of SecM regulates the ...

Scientists have identified a crucial mechanism that allows plants to shape their vascular systems, determining whether they ...

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Experimental evidence has established that SARS-CoV-2 NSP1 acts as a factor that ...